(S,R,S)-AHPC-Me hydrochloride ( VHL ligand 2 hydrochloride,E3 ligase Ligand 1 )

Catalog No. M22711 CAS No. 1948273-03-7

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Product Name

(S,R,S)-AHPC-Me hydrochloride
Note

Research use only, not for human use.
Brief Description

(S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader.
Description

(S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM. (S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.
Synonyms

VHL ligand 2 hydrochloride,E3 ligase Ligand 1
Pathway

PROTACs
Target

E3 Ligase Ligand
Recptor

VHL
Research Area

——
Indication

——

CAS Number

1948273-03-7
Formula Weight

481.05
Molecular Formula

C23H33ClN4O3S
Purity

>98% (HPLC)
Solubility

DMSO:62 mg/mL(128.88 mM)
SMILES

Cl.C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)c1ccc(cc1)-c1scnc1C
Chemical Name

——

1. WO/2017/030814A1

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